{"product_id":"proteogenix-recombinant-human-cxcl10-ip-10-protein-n-his-sumo-c-strep","title":"Recombinant Human CXCL10\/IP-10 Protein, N-His-SUMO \u0026 C-Strep","description":"\u003ch2\u003eIntroduction\u003c\/h2\u003e \u003cp\u003eRecombinant Human CXCL10\/IP-10 Protein, also known as interferon gamma-induced protein 10 (IP-10), is a chemokine protein that plays a crucial role in the immune system. It is produced by various cell types, including monocytes, endothelial cells, fibroblasts, and keratinocytes, in response to interferon-gamma (IFN-γ) stimulation. This protein is involved in a range of biological processes, including inflammation, immune response, and cell migration, making it a valuable tool in both research and clinical applications.\u003c\/p\u003e \u003ch2\u003eStructure of Recombinant Human CXCL10\/IP-10 Protein\u003c\/h2\u003e \u003cp\u003eThe recombinant form of CXCL10\/IP-10 is a 77 amino acid protein with a molecular weight of approximately 8.5 kDa. It is composed of a single chain of amino acids with a conserved N-terminal sequence and a highly variable C-terminal sequence. The protein contains four cysteine residues that form two disulfide bonds, which are essential for maintaining its tertiary structure and biological activity.\u003c\/p\u003e \u003cp\u003eThe three-dimensional structure of CXCL10\/IP-10 consists of a three-stranded β-sheet and an α-helix, which are connected by two loops. The N-terminal region contains the first two β-strands, while the C-terminal region contains the third β-strand and the α-helix. This unique structure allows CXCL10\/IP-10 to interact with its receptors and exert its biological functions.\u003c\/p\u003e \u003ch2\u003eActivity of Recombinant Human CXCL10\/IP-10 Protein\u003c\/h2\u003e \u003cp\u003eCXCL10\/IP-10 is a potent chemoattractant for immune cells, particularly T cells, natural killer (NK) cells, and monocytes. It exerts its activity by binding to its receptors, CXCR3 and CXCR3B, which are expressed on the surface of these cells. This binding triggers a signaling cascade that leads to the activation of various immune cell functions, such as cell migration, adhesion, and cytokine production.\u003c\/p\u003e \u003cp\u003eIn addition to its chemoattractant activity, CXCL10\/IP-10 also has anti-angiogenic properties. It inhibits the growth of new blood vessels by suppressing the proliferation and migration of endothelial cells, which is important in controlling inflammation and tumor growth.\u003c\/p\u003e \u003ch2\u003eApplications of Recombinant Human CXCL10\/IP-10 Protein\u003c\/h2\u003e \u003cp\u003eRecombinant Human CXCL10\/IP-10 Protein has various applications in both research and clinical settings. In research, it is used as a tool to study the role of CXCL10\/IP-10 in various biological processes, including immune response, inflammation, and angiogenesis. It can also be used to investigate the signaling pathways involved in CXCL10\/IP-10-mediated functions.\u003c\/p\u003e \u003cp\u003eIn clinical applications, CXCL10\/IP-10 has been shown to be a potential biomarker for various diseases, such as autoimmune disorders, viral infections, and cancer. Elevated levels of CXCL10\/IP-10 have been observed in patients with rheumatoid arthritis, multiple sclerosis, hepatitis, and various types of cancer. This makes CXCL10\/IP-10 a promising diagnostic and prognostic marker for these diseases.\u003c\/p\u003e \u003cp\u003eFurthermore, recombinant CXCL10\/IP-10 has been used in clinical trials as a therapeutic agent for the treatment of various diseases. It has been shown to have anti-tumor activity in preclinical studies, and clinical trials are currently underway to evaluate its efficacy in cancer treatment. In addition, CXCL10\/IP-10 has been investigated as a potential therapeutic for autoimmune disorders and viral infections, with promising results.\u003c\/p\u003e \u003ch2\u003eConclusion\u003c\/h2\u003e \u003cp\u003eRecombinant Human CXCL10\/IP-10 Protein is a versatile chemokine that plays a crucial role in the immune system. Its unique structure and activity make it a valuable tool in research and a potential biomarker and therapeutic agent in clinical applications. With ongoing research and clinical trials, the full potential\u003c\/p\u003e\u003cp\u003eProteoGenix catalogue number ARO-P11711. For research use only.\u003c\/p\u003e\u003cp\u003eHost: Escherichia coli (E.coli); Expression system: Prokaryotic expression; Molecular weight: 22.27 kDa; Fragment: Val22-Pro98; Buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol..\u003c\/p\u003e\u003cp\u003eAvailable configurations: 50ug, 100ug, 1mg.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.proteogenix.science\/wp-content\/uploads\/documents\/Datasheets\/ARO-P11711.pdf\"\u003eDownload the manufacturer datasheet\u003c\/a\u003e\u003c\/p\u003e","brand":"ProteoGenix","offers":[{"title":"50ug","offer_id":57358934442324,"sku":"ABM142150-1","price":172.0,"currency_code":"GBP","in_stock":true},{"title":"100ug","offer_id":57358934475092,"sku":"ABM142150-2","price":276.0,"currency_code":"GBP","in_stock":true},{"title":"1mg","offer_id":57358934507860,"sku":"ABM142150-3","price":732.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/3d-representation-image-recombinant-human-cxcl10-ip-10-protein-n-his-sumo-c-strep_55056dec-366a-4ed5-9a3d-c02d4cd655ed.webp?v=1790894290","url":"https:\/\/www.abmium.com\/de\/products\/proteogenix-recombinant-human-cxcl10-ip-10-protein-n-his-sumo-c-strep","provider":"ABMIUM","version":"1.0","type":"link"}