{"product_id":"proteogenix-coramitug-biosimilar-anti-transthyretin-mab-research-grade","title":"Coramitug Biosimilar – Anti-Transthyretin mAb – Research Grade","description":"\u003ch3\u003eIntroduction\u003c\/h3\u003e \u003cp\u003eCoramitug Biosimilar is a novel therapeutic antibody that targets transthyretin, a protein involved in various diseases such as amyloidosis and familial amyloid polyneuropathy. This biosimilar is a research grade version of the original antibody, with similar structure and activity but produced at a lower cost, making it more accessible for research purposes.\u003c\/p\u003e \u003ch3\u003eStructure of Coramitug Biosimilar\u003c\/h3\u003e \u003cp\u003eCoramitug Biosimilar is a monoclonal antibody (mAb) with a molecular weight of approximately 150 kDa. It is composed of two heavy chains and two light chains, connected by disulfide bonds. The heavy chains consist of constant and variable regions, while the light chains only have variable regions. The variable regions of the antibody are responsible for binding to the target protein, transthyretin.\u003c\/p\u003e \u003ch3\u003eActivity of Coramitug Biosimilar\u003c\/h3\u003e \u003cp\u003eThe main function of Coramitug Biosimilar is to bind to transthyretin and inhibit its activity. Transthyretin is a protein found in the blood and cerebrospinal fluid, and it plays a role in transporting thyroid hormone and retinol. However, in certain diseases, such as amyloidosis, transthyretin can form abnormal deposits in tissues, leading to organ damage. By binding to transthyretin, Coramitug Biosimilar prevents it from forming these deposits and reduces the associated damage.\u003c\/p\u003e \u003ch3\u003eApplication of Coramitug Biosimilar\u003c\/h3\u003e \u003cp\u003eCoramitug Biosimilar has potential applications in both research and clinical settings. In research, it can be used to study the role of transthyretin in various diseases, as well as to develop new therapies targeting this protein. In clinical settings, it can be used as a treatment for diseases caused by abnormal transthyretin, such as amyloidosis and familial amyloid polyneuropathy.\u003c\/p\u003e \u003ch3\u003eResearch Applications\u003c\/h3\u003e \u003cul\u003e \u003cli\u003eInvestigating the role of transthyretin: Coramitug Biosimilar can be used in laboratory experiments to study the function of transthyretin in different diseases. By inhibiting its activity, researchers can observe the effects on cellular processes and potentially identify new therapeutic targets.\u003c\/li\u003e \u003cli\u003eDeveloping new therapies: The ability of Coramitug Biosimilar to bind to transthyretin can also be utilized in the development of new therapies. By understanding the binding mechanism, researchers can design more effective drugs to target this protein in diseases where it is involved.\u003c\/li\u003e \u003c\/ul\u003e \u003ch3\u003eClinical Applications\u003c\/h3\u003e \u003cul\u003e \u003cli\u003eTreatment of amyloidosis: Amyloidosis is a rare disease characterized by the buildup of abnormal proteins in tissues and organs. Coramitug Biosimilar can be used as a treatment to prevent the formation of these deposits and slow down the progression of the disease.\u003c\/li\u003e \u003cli\u003eTreatment of familial amyloid polyneuropathy: Familial amyloid polyneuropathy is a genetic disorder that affects the nervous system. Coramitug Biosimilar can be used to reduce the accumulation of transthyretin in the nerves, potentially slowing down or preventing nerve damage.\u003c\/li\u003e \u003c\/ul\u003e \u003ch3\u003eConclusion\u003c\/h3\u003e \u003cp\u003eIn summary, Coramitug Biosimilar is a research grade monoclonal antibody that targets transthyretin. Its structure and activity are similar to the original antibody, but it is produced at a lower cost, making it more accessible for research purposes. This biosimilar has potential applications in both research and clinical settings, making it a valuable tool in the study and treatment of diseases involving transthyretin.\u003c\/p\u003e\u003cp\u003eProteoGenix catalogue number PX-TA2113. For research use only.\u003c\/p\u003e\u003cp\u003eTarget: Coramitug Biosimilar – Anti-Transthyretin mAb – Research Grade; Clonality: Monoclonal Antibody; Expression system: XtenCHO; Purity: \u0026gt;95% by SDS-PAGE.; Buffer: 0.01M PBS, pH 7.4.; Applications: ELISA.\u003c\/p\u003e\u003cp\u003eAvailable configurations: 50ug, 100ug, 1mg.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.proteogenix.science\/wp-content\/uploads\/documents\/Datasheets\/PX-TA2113.pdf\"\u003eDownload the manufacturer datasheet\u003c\/a\u003e\u003c\/p\u003e","brand":"ProteoGenix","offers":[{"title":"50ug","offer_id":57357706101076,"sku":"ABM133951-1","price":119.2,"currency_code":"GBP","in_stock":true},{"title":"100ug","offer_id":57357706133844,"sku":"ABM133951-2","price":167.2,"currency_code":"GBP","in_stock":true},{"title":"1mg","offer_id":57357706166612,"sku":"ABM133951-3","price":348.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/sds-validation-1-coramitug-biosimilar-anti-transthyretin-mab-research-grade_8cd64590-2d04-4db2-a952-a2ac50d77621.jpg?v=1790890931","url":"https:\/\/www.abmium.com\/de\/products\/proteogenix-coramitug-biosimilar-anti-transthyretin-mab-research-grade","provider":"ABMIUM","version":"1.0","type":"link"}