{"product_id":"anti-factor-xii-f12-antibody-picoband-a01226-4","title":"Anti-Factor XII\/F12 Antibody Picoband®","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProduct profile:\u003c\/strong\u003e Reactivity: Human, Mouse, Rat; Host: Rabbit; Clonality: Polyclonal; Isotype: Rabbit IgG.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplications:\u003c\/strong\u003e WB,ELISA.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eRecommended conditions:\u003c\/strong\u003e Western blot, 0.25-0.5 μg\/ml, Human, Mouse, Rat\u0026lt;br\u0026gt; ELISA, 0.1-0.5 μg\/ml\u0026lt;br\u0026gt;\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTechnical details:\u003c\/strong\u003e Immunogen: E.coli-derived human Factor XII\/F12 recombinant protein (Position: E24-H538).; Purification: Immunogen affinity purified.; Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg\/ml.; Observed MW: 52 kDa; Calculated MW: 68 kDa.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e At -20˚C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freezing and thawing.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eResearch Use Only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Boster Bio","offers":[{"title":"Unconjugated \/ 100 μg\/vial","offer_id":57460929069396,"sku":"ABM149072-1","price":262.65,"currency_code":"GBP","in_stock":true},{"title":"Biotin \/ 100 μg\/vial","offer_id":57460929102164,"sku":"ABM149072-2","price":398.65,"currency_code":"GBP","in_stock":true},{"title":"Cy3 \/ 100 μg\/vial","offer_id":57460929134932,"sku":"ABM149072-3","price":398.65,"currency_code":"GBP","in_stock":true},{"title":"Fluoro488 \/ 100 μg\/vial","offer_id":57460929167700,"sku":"ABM149072-4","price":398.65,"currency_code":"GBP","in_stock":true},{"title":"Fluoro550 \/ 100 μg\/vial","offer_id":57460929200468,"sku":"ABM149072-5","price":398.65,"currency_code":"GBP","in_stock":true},{"title":"Fluoro594 \/ 100 μg\/vial","offer_id":57460929233236,"sku":"ABM149072-6","price":398.65,"currency_code":"GBP","in_stock":true},{"title":"FITC \/ 100 μg\/vial","offer_id":57460929266004,"sku":"ABM149072-7","price":398.65,"currency_code":"GBP","in_stock":true},{"title":"HRP \/ 100 μg\/vial","offer_id":57460929298772,"sku":"ABM149072-8","price":398.65,"currency_code":"GBP","in_stock":true},{"title":"APC \/ 100 μg\/vial","offer_id":57460929331540,"sku":"ABM149072-9","price":577.15,"currency_code":"GBP","in_stock":true},{"title":"PE \/ 100 μg\/vial","offer_id":57460929364308,"sku":"ABM149072-10","price":577.15,"currency_code":"GBP","in_stock":true},{"title":"Fluoro647 \/ 100 μg\/vial","offer_id":57460929397076,"sku":"ABM149072-11","price":475.15,"currency_code":"GBP","in_stock":true},{"title":"Carrier-free \/ 100 μg\/vial","offer_id":57460929429844,"sku":"ABM149072-12","price":262.65,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/boster-a01226-4-1_39e2f99e-22d2-412c-9e8e-e233de42def0.jpg?v=1792017637","url":"https:\/\/www.abmium.com\/de\/products\/anti-factor-xii-f12-antibody-picoband-a01226-4","provider":"ABMIUM","version":"1.0","type":"link"}