{"product_id":"abm218544","title":"Human 5-Hydroxytryptamine Receptor 2A, HTR2A ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eG-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed: 1330647, PubMed: 18703043, PubMed: 19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed: 28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed: 28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed: 28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed: 18703043, PubMed: 28129538). Affects neural activity, perception, cognition and mood (PubMed: 18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. (Microbial infection) Acts as a receptor for human JC polyomavirus\/JCPyV.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661856940372,"sku":"ABM218544","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661856973140,"sku":"ABM218545","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-09dc3d473fb7f64c7f73172af3865413279ae4c9f52513d12bba78b2ea899729.jpg?v=1792159219","url":"https:\/\/www.abmium.com\/de\/products\/abm218544","provider":"ABMIUM","version":"1.0","type":"link"}