{"product_id":"abm217710","title":"Human Serine\/Arginine-rich Splicing Factor 1, SFRS1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003ePlays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC\/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF\/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP\/NXF1 pathway.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661764108628,"sku":"ABM217710","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661764141396,"sku":"ABM217711","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-0105efadcac08d727c8d980e32285e38416e6d27eb72406215a8139b1398497b.jpg?v=1792159209","url":"https:\/\/www.abmium.com\/de\/products\/abm217710","provider":"ABMIUM","version":"1.0","type":"link"}