{"product_id":"abm217466","title":"Human Protein Hexim1, HEXIM1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eTranscriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57662008426836,"sku":"ABM217466","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57662008459604,"sku":"ABM217467","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-ad8865415786f525cc614f4a3de4d47462624e42dfbf7a98beed1e3b1c5d8209.jpg?v=1792159241","url":"https:\/\/www.abmium.com\/de\/products\/abm217466","provider":"ABMIUM","version":"1.0","type":"link"}