{"product_id":"abm217220","title":"Human Nucleophosmin, NPM1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eInvolved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53\/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic\/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2\/PKR and suppresses apoptosis through inhibition of EIF2AK2\/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2\/M blockade (PubMed: 22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed: 25956029).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661828530516,"sku":"ABM217220","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661828563284,"sku":"ABM217221","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-7f16d8adc4d53f5fc59da4ec452630ea7f1fae009f0b1688a77c8ee6beb117a9.jpg?v=1792159223","url":"https:\/\/www.abmium.com\/de\/products\/abm217220","provider":"ABMIUM","version":"1.0","type":"link"}