{"product_id":"abm216816","title":"Human Kelch-like Ech-associated Protein 1, KEAP1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eSubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2\/NRF2 for ubiquitination (PubMed: 1$458.00|$300.005973, PubMed: 15379550, PubMed: 15572695, PubMed: 15983046, PubMed: 15601839). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2\/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed: 15601839, PubMed: 16006525). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2\/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed: 19489739, PubMed: 16006525, PubMed: 17127771, PubMed: 18251510, PubMed: 29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1\/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2\/NRF2 (PubMed: 20452972). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1\/p62, increasing SQSTM1\/p62 sequestering activity and degradation (PubMed: 28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed: 15379550, PubMed: 17046835).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57662046601556,"sku":"ABM216816","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57662046634324,"sku":"ABM216817","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-8420a0d74c21fec46e35bf74ab33987c82363c3b3c32f295c2196b7293d0e4f9.jpg?v=1792159244","url":"https:\/\/www.abmium.com\/de\/products\/abm216816","provider":"ABMIUM","version":"1.0","type":"link"}