{"product_id":"abm215866","title":"Human Acidic Leucine-rich Nuclear Phosphoprotein 32 Family Member A, ANP32A ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eMultifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed: 16341127, PubMed: 11360199, PubMed: 18439902, PubMed: 10400610). Promotes apoptosis by favouring the activation of caspase-9\/CASP9 and allowing apoptosome formation (PubMed: 18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300\/CREBBP (CREB-binding protein) and EP300\/CREBBP-associated factor by histone masking (PubMed: 11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed: 16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed: 18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed: 15642345, PubMed: 17557114). (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed: 32694517, PubMed: 33045004, PubMed: 33208942, PubMed: 30666459). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed: 33208942). Plays also an essential role in foamy virus mRNA export from the nucleus (PubMed: 21159877).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661801038164,"sku":"ABM215866","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661801070932,"sku":"ABM215867","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-37c4e3bb07fe4c5b55b8266bbdfe4c768e3b8c6d743c83c87fbe10e48206eb71.jpg?v=1792159225","url":"https:\/\/www.abmium.com\/de\/products\/abm215866","provider":"ABMIUM","version":"1.0","type":"link"}