{"product_id":"abm215574","title":"Human Hla Class 2 Histocompatibility Antigen Gamma Chain, CD74 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003ePlays a critical role in MHC class II antigen processing by stabilizing Peptide-free class II alpha\/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal\/lysosomal system where the antigen processing and binding of antigenic Peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. [Class-II-associated invariant chain Peptide]: Binds to the Peptide-binding site of MHC class II alpha\/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic Peptides to the MHC class II complex until its release by HLA-DM in the endosome. [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed: 32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed: 32855215).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57662062952788,"sku":"ABM215574","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57662062985556,"sku":"ABM215575","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-ae05f0382874627a6c172e6f1025534602508382805b6e2cbf732c671266f6ba.jpg?v=1792159207","url":"https:\/\/www.abmium.com\/de\/products\/abm215574","provider":"ABMIUM","version":"1.0","type":"link"}