{"product_id":"abm213538","title":"Mouse Ubiquitin-like Modifier-activating Enzyme 1, UBA1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eCatalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1511901). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57662006722900,"sku":"ABM213538","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57662006755668,"sku":"ABM213539","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-7c24f718db70fad76fbfc50553b900b619d0f8f3b39776ed4ffb9f48a7cfe1b2.jpg?v=1792159210","url":"https:\/\/www.abmium.com\/de\/products\/abm213538","provider":"ABMIUM","version":"1.0","type":"link"}