{"product_id":"abm213524","title":"Human Sorting Nexin 2, SNX2 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eInvolved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed: 16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed: 17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed: 23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed: 20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed: 20604901).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661996728660,"sku":"ABM213524","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661996761428,"sku":"ABM213525","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-469ab99c410f46696b274e679dc4535c75cc7c8761081dfba37fd55ef62901c4.jpg?v=1792159209","url":"https:\/\/www.abmium.com\/de\/products\/abm213524","provider":"ABMIUM","version":"1.0","type":"link"}