{"product_id":"abm212992","title":"Human Methionyl Aminopeptidase 2, METAP2 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eCotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val Peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2\/PKR and EIF2AK1\/HCR. Plays a critical role in the regulation of protein synthesis.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57662081171796,"sku":"ABM212992","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57662081204564,"sku":"ABM212993","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-3de9fee4bd9f53dba75f9b9846d539bf3e1ebbdb63828d29dac4d5d2f273dcf8.jpg?v=1792159219","url":"https:\/\/www.abmium.com\/de\/products\/abm212992","provider":"ABMIUM","version":"1.0","type":"link"}