{"product_id":"abm212990","title":"Mouse Protein Disulfide-isomerase, P4HB ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form\/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP (By similarity). Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57662080483668,"sku":"ABM212990","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57662080516436,"sku":"ABM212991","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-612526366bcd4f5e39c5fd1bc8340f4945731ea9f7d32b5b570740e1ebf0455a.jpg?v=1792159219","url":"https:\/\/www.abmium.com\/de\/products\/abm212990","provider":"ABMIUM","version":"1.0","type":"link"}