{"product_id":"abm212940","title":"Human Frizzled-7, FZD7 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eReceptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity). Following ligand activation, binds to CCDC88C\/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (PubMed:26126266). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and\/or in differentiated tissues. (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57662068556116,"sku":"ABM212940","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57662068588884,"sku":"ABM212941","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-a0476a72ca3d3df81aed421f9881349d150ef6631afccfe4a3a78db11d365687.jpg?v=1792159215","url":"https:\/\/www.abmium.com\/de\/products\/abm212940","provider":"ABMIUM","version":"1.0","type":"link"}