{"product_id":"abm212452","title":"Human Caspase 14, CASP14 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eNon-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed: 15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed: 16854378, PubMed: 19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed: 25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA\/ICAD leading to liberation of DFFB\/CAD (PubMed: 24743736).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661652173140,"sku":"ABM212452","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661652205908,"sku":"ABM212453","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-429927aee3017845403a252344ee082f883c814d8e01a60a871b2dbb4ab8feef.jpg?v=1792159234","url":"https:\/\/www.abmium.com\/de\/products\/abm212452","provider":"ABMIUM","version":"1.0","type":"link"}