{"product_id":"abm212104","title":"Mouse Interleukin-27 Subunit Beta, EBI3 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eAssociates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma\/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1\/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661819388244,"sku":"ABM212104","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661819421012,"sku":"ABM212105","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-ef64554df781abfcc4db5ebd04e3ba91cc166d6a6b42cfd803129cffada4a858.jpg?v=1792159205","url":"https:\/\/www.abmium.com\/de\/products\/abm212104","provider":"ABMIUM","version":"1.0","type":"link"}