{"product_id":"abm211866","title":"Rat Kelch-like Ech-associated Protein 1, KEAP1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eSubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2\/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2\/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2\/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes. In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1\/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2\/NRF2. The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1\/p62, increasing SQSTM1\/p62 sequestering activity and degradation (By similarity). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661667115348,"sku":"ABM211866","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661667148116,"sku":"ABM211867","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-dd6c3d618bc0b6676cdb3119284cb9c85aa0b30ce0b61db55f3476c1a6b8205a.jpg?v=1792159243","url":"https:\/\/www.abmium.com\/de\/products\/abm211866","provider":"ABMIUM","version":"1.0","type":"link"}