{"product_id":"abm210738","title":"Human Caveolin-1, CAV-1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eMay act as a scaffolding protein within caveolar membranes (PubMed: 11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1\/2\/3\/4) to the caveolae (PubMed: 19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor\/CD3-dependent manner (PubMed: 17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2\/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed: 25893292).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661774725460,"sku":"ABM210738","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661774758228,"sku":"ABM210739","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-dcf6a9590669f3749404cd9f8193490fdeffdaa33b910a04fb674e7f27da0db8.jpg?v=1792159205","url":"https:\/\/www.abmium.com\/de\/products\/abm210738","provider":"ABMIUM","version":"1.0","type":"link"}