{"product_id":"abm210250","title":"Rat 3 Beta-Hydroxysteroid Dehydrogenase, Delta 5--＞4-isomerase Type 1, HSD3B1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eA bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta5-steroid precursors to 3-oxo-Delta4-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone (PubMed:1537836, PubMed:1985917). Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor\/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone (PubMed:1537836). Expected to use NAD+ as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57662033363284,"sku":"ABM210250","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57662033396052,"sku":"ABM210251","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-2b2cf8d0d5074af7e10b88b642fdd4b54d4d4c316674fecc79742c8b054b4333.jpg?v=1792159220","url":"https:\/\/www.abmium.com\/de\/products\/abm210250","provider":"ABMIUM","version":"1.0","type":"link"}