{"product_id":"abm208458","title":"Human Complement Component 5, C5 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eActivation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed: 8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"96T","offer_id":57662034280788,"sku":"ABM208458","price":293.0,"currency_code":"GBP","in_stock":true},{"title":"48T","offer_id":57662034313556,"sku":"ABM208459","price":205.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-fa5ce742af1d9744506947e95025ee23ba0bfa2c12785478f07c4c47e1687dc0.jpg?v=1792159155","url":"https:\/\/www.abmium.com\/de\/products\/abm208458","provider":"ABMIUM","version":"1.0","type":"link"}