{"product_id":"abm207952","title":"Canine Insulin-like Growth Factors 1, IGF-1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe Insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT\/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3\/ERK1, MAPK1\/ERK2 and AKT1 (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"96T","offer_id":57661647487316,"sku":"ABM207952","price":304.0,"currency_code":"GBP","in_stock":true},{"title":"48T","offer_id":57661647520084,"sku":"ABM207953","price":224.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-60110e4dc2c1a5b39377fd174bb5ce7a70791eab4901e14589705268078142d0.jpg?v=1792159120","url":"https:\/\/www.abmium.com\/de\/products\/abm207952","provider":"ABMIUM","version":"1.0","type":"link"}