{"product_id":"abm207812","title":"Human Stem Cell Factor\/Mast Cell Growth Factor, SCF\/MGF ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eLigand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG\/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG\/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1\/ERK2 and\/or MAPK3\/ERK1. KITLG\/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG\/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG\/SCF acts synergistically with other cytokines, probably interleukins.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"96T","offer_id":57661439115604,"sku":"ABM207812","price":293.0,"currency_code":"GBP","in_stock":true},{"title":"48T","offer_id":57661439148372,"sku":"ABM207813","price":205.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-ef7a076637354437ebc4f47494ea31d7d814853c6698526ed8209bb5e1ffe583.jpg?v=1792159109","url":"https:\/\/www.abmium.com\/de\/products\/abm207812","provider":"ABMIUM","version":"1.0","type":"link"}