{"product_id":"abm207446","title":"Human Interleukin 28A, IL-28A ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eCytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK\/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"96T","offer_id":57661094822228,"sku":"ABM207446","price":293.0,"currency_code":"GBP","in_stock":true},{"title":"48T","offer_id":57661094854996,"sku":"ABM207447","price":205.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-7e4f0fd27e00ab7ac9ff682245a5d8691a507031d15fce1fdb59947f60d46273.jpg?v=1792159083","url":"https:\/\/www.abmium.com\/de\/products\/abm207446","provider":"ABMIUM","version":"1.0","type":"link"}