{"product_id":"abm207250","title":"Mouse Interleukin 11, IL-11 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eCytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed: 8913282). Also promotes the proliferation of hepatocytes in response to liver damage (PubMed: 22253262). Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers (PubMed: 10026196, PubMed: 23948300). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3 (PubMed: 23948300, PubMed: 22253262). The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57660905947476,"sku":"ABM207250","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57660905980244,"sku":"ABM207251","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-d10108d445b780cdb3705830574a3b7b5c4065c5830ae1d803f8bd986e4b8c5e.jpg?v=1792159165","url":"https:\/\/www.abmium.com\/de\/products\/abm207250","provider":"ABMIUM","version":"1.0","type":"link"}