{"product_id":"abm206433","title":"SNAI1 Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eSnail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57661176381780,"sku":"ABM206433","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57661176414548,"sku":"ABM206434","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-ffcbf787f29f79f943096392dfce16725dd08ff36b646fa7202fd4da6a847378.jpg?v=1792159123","url":"https:\/\/www.abmium.com\/de\/products\/abm206433","provider":"ABMIUM","version":"1.0","type":"link"}