{"product_id":"abm205885","title":"PDHA1 Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57661331702100,"sku":"ABM205885","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57661331734868,"sku":"ABM205886","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-0ad3ca1ebbb8798f28ec31f26a9470f7c850f7de902409ca9558b568cc086368.jpg?v=1792159079","url":"https:\/\/www.abmium.com\/de\/products\/abm205885","provider":"ABMIUM","version":"1.0","type":"link"}