{"product_id":"abm204589","title":"ZAP70 Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57660827337044,"sku":"ABM204589","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57660827369812,"sku":"ABM204590","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-129e79c219c0dc5829b8f93dc2070a9f7b2278b4ab6b4e389f329dc35991a192.jpg?v=1792159115","url":"https:\/\/www.abmium.com\/de\/products\/abm204589","provider":"ABMIUM","version":"1.0","type":"link"}