{"product_id":"abm202495","title":"TNK1 Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eTNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase(NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF\/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57661190373716,"sku":"ABM202495","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57661190406484,"sku":"ABM202496","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-83284adb17c468b6d053723991c1c15e5e315d94dac571a70c01931a7ea219bf.jpg?v=1792159129","url":"https:\/\/www.abmium.com\/de\/products\/abm202495","provider":"ABMIUM","version":"1.0","type":"link"}