{"product_id":"abm202217","title":"PAR4 Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eProstate apoptosis response 4 (Par4) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. The tumor suppressor WT1 represses and activates transcription. The loss and\/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. Par4 is a WT1 interacting protein that also functions as a transcriptional repressor.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57660889104724,"sku":"ABM202217","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57660889137492,"sku":"ABM202218","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-e47b356b8c68f2679d2a79f17dcc93a3c53a7573eb28ba2d75a90c4e9b859979.jpg?v=1792159140","url":"https:\/\/www.abmium.com\/de\/products\/abm202217","provider":"ABMIUM","version":"1.0","type":"link"}