{"product_id":"abm200881","title":"SETD7 Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eHistone methyltransferase that specifically monomethylates Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1\/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53\/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates Lys-189 of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates Lys-372 of p53\/TP53, stabilizing p53\/TP53 and increasing p53\/TP53-mediated transcriptional activation.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57661153149268,"sku":"ABM200881","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57661153182036,"sku":"ABM200882","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-a4f3bfb4385b1de72e641a1e195f6db1bfd9ac8134e53e4036bb35449bfa115f.jpg?v=1792158997","url":"https:\/\/www.abmium.com\/de\/products\/abm200881","provider":"ABMIUM","version":"1.0","type":"link"}