{"product_id":"abm200422","title":"RAG-2 Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodef\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"50ul","offer_id":57660736733524,"sku":"ABM200422","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660736766292,"sku":"ABM200423","price":192.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-a0deddbd639e369ff1a30a8106b9d799d8dc1c524477e869986ebac4b39fb3c1.jpg?v=1792159030","url":"https:\/\/www.abmium.com\/de\/products\/abm200422","provider":"ABMIUM","version":"1.0","type":"link"}