{"product_id":"abm199242","title":"Cortactin Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"50ul","offer_id":57661323149652,"sku":"ABM199242","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57661323182420,"sku":"ABM199243","price":192.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1433e3265c297d552eb43fc007af4eb67d1565d8df5028cbb2c0f71b79ee0ac0.jpg?v=1792158971","url":"https:\/\/www.abmium.com\/de\/products\/abm199242","provider":"ABMIUM","version":"1.0","type":"link"}