{"product_id":"abm196352","title":"CR1 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and\/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57660804661588,"sku":"ABM196352","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660804694356,"sku":"ABM196353","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57660804727124,"sku":"ABM196354","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1ea4c7287cbfdf5088445786c5a5187a69f59f2a2d1db38ede993084a9fd9773.jpg?v=1792241051","url":"https:\/\/www.abmium.com\/de\/products\/abm196352","provider":"ABMIUM","version":"1.0","type":"link"}