{"product_id":"abm196043","title":"TIRAP(Phospho Tyr86) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57661458809172,"sku":"ABM196043","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661458841940,"sku":"ABM196044","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57661458874708,"sku":"ABM196045","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-d6c25a1ee4fda3cf5aef9b6196a05c6a91c5e54af6e3343fd69dfeb4dec08403.jpg?v=1792158998","url":"https:\/\/www.abmium.com\/de\/products\/abm196043","provider":"ABMIUM","version":"1.0","type":"link"}