{"product_id":"abm195497","title":"CD204 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57661073359188,"sku":"ABM195497","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661073391956,"sku":"ABM195498","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57661073424724,"sku":"ABM195499","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-b39c4388c4efa617e222b493232de4e1adb6a40db6c41942e3e2dce9aa2fd8e8.jpg?v=1792158960","url":"https:\/\/www.abmium.com\/de\/products\/abm195497","provider":"ABMIUM","version":"1.0","type":"link"}