{"product_id":"abm191801","title":"Rad17(Phospho Ser645) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, h\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57661038952788,"sku":"ABM191801","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661038985556,"sku":"ABM191802","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57661039018324,"sku":"ABM191803","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-119ff35496c3f05f19270d7af5b6db731bd82d8907c8c80d0b7a15f1009ce0d5.jpg?v=1792158994","url":"https:\/\/www.abmium.com\/de\/products\/abm191801","provider":"ABMIUM","version":"1.0","type":"link"}