{"product_id":"abm190730","title":"TPOR(Phospho-Tyr626) Rabbit Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eIn 1990 an oncogene| v-mpl| was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue| named| c-mpl| was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl| thrombopoietin| was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene| CD110| is a 635 amino acid transmembrane domain| with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic| emphasizing the important\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57661101572436,"sku":"ABM190730","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661101605204,"sku":"ABM190731","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57661101637972,"sku":"ABM190732","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1ea4c7287cbfdf5088445786c5a5187a69f59f2a2d1db38ede993084a9fd9773.jpg?v=1792241051","url":"https:\/\/www.abmium.com\/de\/products\/abm190730","provider":"ABMIUM","version":"1.0","type":"link"}