{"product_id":"abm190301","title":"TCA Rabbit Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eT cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell| the T cell receptor loci are rearranged and expressed in the order delta| gamma| beta| and alpha. If both delta and gamma rearrangements produce functional chains| the cell expresses delta and gamma. If not| the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable)| J (joining)| and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus| between the alpha V and J segments. During T cell development| the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains| the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity| resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV\/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660785525076,"sku":"ABM190301","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660785557844,"sku":"ABM190302","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660785590612,"sku":"ABM190303","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-81aa7e12125502c970026cdf1a7a93eaf547c27f2c8acb2dbddb00df46dda8ef.jpg?v=1792159028","url":"https:\/\/www.abmium.com\/de\/products\/abm190301","provider":"ABMIUM","version":"1.0","type":"link"}