{"product_id":"abm189389","title":"Smad1(Phospho Ser214) Rabbit Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eTranscriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).|PTM:Phosphorylated on serine by BMP type 1 receptor kinase.|PTM:Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.|Belongs to the dwarfin\/SMAD family.|Contains 1 MH1 (MAD homology 1) domain.|Contains 1 MH2 (MAD homology 2) domain.|subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.|subunit:Interacts with HGS| NANOG and ZCCHC12 (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit| CREB-binding protein (CBP)| p300| SMURF1| SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with LBXCOR1.|tissue specificity:Ubiquitous. Highest expression seen in the heart and skeletal muscle.|\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57660990390612,"sku":"ABM189389","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660990423380,"sku":"ABM189390","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57660990456148,"sku":"ABM189391","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1ea4c7287cbfdf5088445786c5a5187a69f59f2a2d1db38ede993084a9fd9773.jpg?v=1792241051","url":"https:\/\/www.abmium.com\/de\/products\/abm189389","provider":"ABMIUM","version":"1.0","type":"link"}