{"product_id":"abm186040","title":"NPC1 Rabbit Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus| 13 transmembrane domains| and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal\/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease| a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal\/lysosomal compartments.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57661218980180,"sku":"ABM186040","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661219012948,"sku":"ABM186041","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57661219045716,"sku":"ABM186042","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-f80a2a0895a73db27977dc619da78b4a9baaff13f3dedf7c0e464f745ce2b4e4.jpg?v=1792159050","url":"https:\/\/www.abmium.com\/de\/products\/abm186040","provider":"ABMIUM","version":"1.0","type":"link"}