{"product_id":"abm184885","title":"MCM4(Phospho Ser54) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC\/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcri\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57661190209876,"sku":"ABM184885","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661190242644,"sku":"ABM184886","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57661190275412,"sku":"ABM184887","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-6b6ce25cc05ebb6c26d87aa4e3de4060a7d00422cf7828b2ee31136896070196.jpg?v=1792159000","url":"https:\/\/www.abmium.com\/de\/products\/abm184885","provider":"ABMIUM","version":"1.0","type":"link"}