{"product_id":"abm179473","title":"UBE3B Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: e1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. UBE3B (ubiquitin protein ligase E3B) encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for UBE3B.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57659771879764,"sku":"ABM179473","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57659771912532,"sku":"ABM179474","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57659771945300,"sku":"ABM179475","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-bf0848cc506434fd2efdb8ccdc705fba292dd0bb7994451fdb5e35b8c3f524a1.jpg?v=1792158872","url":"https:\/\/www.abmium.com\/de\/products\/abm179473","provider":"ABMIUM","version":"1.0","type":"link"}