{"product_id":"abm175813","title":"TBC1D4(Phospho Thr642) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene is a member of the Tre-2\/BUB2\/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein| and contains two phopshotyrosine-binding domains (PTB1 and PTB2)| a calmodulin-binding domain (CBD)| a Rab-GTPase domain| and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4)| important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane| suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin| this protein is phosphorylated| dissociates from GLUT4 vesicles| resulting in increased GLUT4 at the cell surface| and enhanced glucose transport. Ph\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57659728265556,"sku":"ABM175813","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57659728298324,"sku":"ABM175814","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57659728331092,"sku":"ABM175815","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-89db5ca5b0963ce1a1507db7fc8f118ca5731baf74a4023214d94ed5199263d6.jpg?v=1792158816","url":"https:\/\/www.abmium.com\/de\/products\/abm175813","provider":"ABMIUM","version":"1.0","type":"link"}