{"product_id":"abm174799","title":"RFWD3 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eRFWD3, also named as RNF201, is a E3 ubiquitin-protein ligase that mediates the ubiquitination of p53\/TP53 in the late response to DNA damage, and acts as a positive regulator of p53\/TP53 stability, thereby regulating the G1\/S DNA damage checkpoint. RFWD3 may act by catalyzing the formation of short polyubiquitin chains on p53\/TP53 that are not targeted to the proteasome. In response to ionizing radiation, It interacts with MDM2 and enhances p53\/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53\/TP53. (PMID: 20173098 ) From BLAST result, this antibody is specific to RFWD3. 45kd and 55kd maybe splicesome of RFWD3.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57659870249300,"sku":"ABM174799","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57659870282068,"sku":"ABM174800","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57659870314836,"sku":"ABM174801","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-a474837a299dfb362f179f51ce1ba57132b8858f67ac6dc06e68760fd2a01b3e.jpg?v=1792158836","url":"https:\/\/www.abmium.com\/de\/products\/abm174799","provider":"ABMIUM","version":"1.0","type":"link"}