{"product_id":"abm171364","title":"HER2(Phospho-Tyr1139) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However| it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer| stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways| such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported| with the most common allele| Ile654\/Ile655| shown here. Amplification and\/or overexpression of this gene has been reported in numerous cancers| including breast and ovarian tumors. Alternative splicing results in several additional transcript variants| some encoding d\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57660050276692,"sku":"ABM171364","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660050309460,"sku":"ABM171365","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57660050342228,"sku":"ABM171366","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1ea4c7287cbfdf5088445786c5a5187a69f59f2a2d1db38ede993084a9fd9773.jpg?v=1792241051","url":"https:\/\/www.abmium.com\/de\/products\/abm171364","provider":"ABMIUM","version":"1.0","type":"link"}