{"product_id":"abm166279","title":"SPTA1 Rabbit Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eSpectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton| and functions in the determination of cell shape| arrangement of transmembrane proteins| and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin| which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders| including elliptocytosis type 2| pyropoikilocytosis| and spherocytic hemolytic anemia.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57659784134996,"sku":"ABM166279","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57659784167764,"sku":"ABM166280","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57659784200532,"sku":"ABM166281","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-ff2dd5c1a1be294a8c56beab7da052d56973de0911817b38ae62598ec5ac9e45.jpg?v=1792158835","url":"https:\/\/www.abmium.com\/de\/products\/abm166279","provider":"ABMIUM","version":"1.0","type":"link"}