{"product_id":"abm165850","title":"Shc(Phospho-Tyr317) Rabbit Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways| the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms| p52Shc and p46Shc| link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2\/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms| p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57660484485460,"sku":"ABM165850","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660484518228,"sku":"ABM165851","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57660484550996,"sku":"ABM165852","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1ea4c7287cbfdf5088445786c5a5187a69f59f2a2d1db38ede993084a9fd9773.jpg?v=1792241051","url":"https:\/\/www.abmium.com\/de\/products\/abm165850","provider":"ABMIUM","version":"1.0","type":"link"}