{"product_id":"abm160807","title":"ErbB-4 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eERBB4 is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The erb-b2 receptor tyrosine kinase 4 binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660287713620,"sku":"ABM160807","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660287746388,"sku":"ABM160808","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660287779156,"sku":"ABM160809","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-19669ee01e2d66d49f1da8ac59cc29563ad57474e11eb76fe267723c6ed8bbcf.jpg?v=1792157360","url":"https:\/\/www.abmium.com\/de\/products\/abm160807","provider":"ABMIUM","version":"1.0","type":"link"}