{"product_id":"abm157330","title":"Cleaved-Caspase-1 (D210) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eCASP1 (caspase 1) encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. CASP1 was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. CASP1 has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660286533972,"sku":"ABM157330","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660286566740,"sku":"ABM157331","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660286599508,"sku":"ABM157332","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-35376bdea09d384ae3d58b734d1e9942a213e241bfe598fdb43c97e1d7e7a6aa.jpg?v=1792157338","url":"https:\/\/www.abmium.com\/de\/products\/abm157330","provider":"ABMIUM","version":"1.0","type":"link"}